The film follows a mercenary named Royce (Adrien Brody), who is abducted by alien creatures known as the Predators. He is released onto an alien planet—which acts as a game preserve—along with seven other humans who, with the exception of a disgraced physician, are all cold-blooded killers, with the group consisting of mercenaries and convicts. Royce reluctantly leads the group of elite warriors as they come to realize they have been brought together on this planet as prey for a new breed of Predators. While battling to survive against these creatures, they come across an American soldier known as Noland, who was brought to the planet years ago as game, but has managed to survive by hiding from the Predators in a cave. Noland reveals that the Predators have been hunting humans by dropping them on this planet for many years.